Telomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres.
The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammalians. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here.
Two chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.
1. Telomeres: All’s Well That Ends Well, Patrizia Alberti.
2. Methods to Measure Telomere Lengths, Lauréline Roger.
3. The Shelterin Complex, Claire Ghilain, Eric Gilson and Marie-Josèphe Giraud-Panis.
4. Mammalian Telomere Organization and Dynamics in the Nuclear Volume, Sonia Stinus and Laure Crabbe.
5. Saccharomyces cerevisiae, a Model at the Forefront of Telomere Biology, Aurélia Barascu and Maria Teresa Teixeira.
6. Dealing with Replication Stress at Telomeres, Stéphane Coulon.
7. A Brief History of Telomerase: Exceptional Women in Command, Vincent Géli.
8. Telomerase: Structure and Mechanism, Carole Saintomé.
9. Alternative Lengthening of Telomeres, Mathilde Gauchier.
10. TERRA, Telomeric Non-coding RNAs, Anabelle Decottignies.
11. Telomeres and Cancer, Arturo Londono-Vallejo.
12. Physiopathology of Telomeres, Caroline Kannengiesser and Patrick Revy.
13. Telomeres Targeting Agents, Sophie Bombard, Patrick Maillet and Marie-Paule Teulade-Fichou.
Carole Saintomé is Assistant Professor in Biochemistry at Sorbonne Université, France. She studies the role of single-stranded DNA binding proteins at telomeres and their interactions with G-quadruplexes DNA structures at the Muséum national d’Histoire naturelle, France.
Table of Contents
PDF File 154 Kb